In India HIV/AIDS came into public view in 1986 with detection of first few cases of Hiv in chennai,Tamil Nadu and first AIDS cases in Mumbai in 1987. IThe first indication of AIDS was observed in 1981 with reports from New york and Los Angeles of sudden unexplained outbreak of 2 very rare diseases , Kaposi's Sarcoma & Pneumocystic carinii pneumonia in young adults who werehomosexcuals & drug addicts A blood test can determine if a person is infected with HIV, but if a person tests positive for HIV, it does not necessarily mean that the person has AIDS. A diagnosis of AIDS is made by a physician according to the CDC AIDS Case Definition. A person infected with HIV may receive an AIDS diagnosis after developing one of the CDC-defined AIDS indicator illnesses.

GeneStructureClinical Significance
Genesdetermines the core and shell of the virusThe major core antigen is p24 which can be detected in serum during the early stages of HIV infection before antibodies appear.Late in the course of infection, the decline of free anti p24 antibody and reappearance of p24 antigen in circulation point to exacerbation of the illness.
gagStructureClinical Significance
env23
GeneStructureClinical Significance
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GeneStructureClinical Significance
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GeneStructureClinical Significance
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GeneStructureClinical Significance
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GeneStructureClinical Significance
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The sera of infected person contains antibodies to the antigens.Detection of these antigens and antibodies is useful in the diagnosis and prognosis of HIV infection.
Evelope antigens1. Spike antigen - gp(Principal envelope antigen)
2. Transmembrance pedicle protein - gp41
Shell antigenNucleocapsid protein-p18
Core antigens1. Principal core antigen - p24
2. Other core antigens - p15,p55
Polymerasep31, p51, p66